Theophylline-induced synergic activation of guide RNA to control CRISPR/Cas9 function
Chemical Communications2021Vol. 57(44), pp. 5418–5421
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Abstract
Ligand-induced activation of CRISPR/Cas9 function is achieved based on a synergic approach through the integration of the theophylline aptamer into protein-unrecognized regions of guide RNA. This design of allosteric regulation opens a new window towards the broad involvement of RNA aptamers for conditional control of CRISPR/Cas9 function.
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- [Therapeutic concentrations of theophylline and caffeine during treatment of apnea in premature infants with theophylline].(1985)
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