A fluorogenic probe targeting two spatially separated enzymes for selective imaging of cancer cells
Chemical Communications2022Vol. 58(25), pp. 4079–4082
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Abstract
We describe a fluorogenic probe BocLys(Ac)-AB-FC targeting both histone deacetylases (HDACs) and cathepsin L, which are overexpressed in spatially separated subcellular organelles of cancer cells. The results show that this fluorogenic probe can be used for selective cancer cell imaging without interference arising from normal cells.
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