Biochemical characterization of a cyanobactin arginine-N-prenylase from the autumnalamide biosynthetic pathway
Chemical Communications2022Vol. 58(86), pp. 12054–12057
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Claudia Clemente, Nicholas Johnson, Xiaodan Ouyang, Rafael Vicentini Popin, Sergio Dall’Angelo, Matti Wahlsten, Jouni Jokela, Alessandro Colombano, Brunello Nardone, David P. Fewer, Wael E. Houssen
Abstract
Cyanobactins are linear and cyclic post-translationally modified peptides. Here we show that the prenyl-D-Arg-containing autumnalamide A is a member of the cyanobactin family. Biochemical assays demonstrate that the AutF prenyltransferase targets the guanidinium moiety in arginine and homoarginine and is a useful tool for biotechnological applications.
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