Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues
Chemical Communications2022Vol. 58(57), pp. 7928–7931
Citations Over TimeTop 24% of 2022 papers
Mariama Djaló, Maria J. S. A. Silva, Hélio Faustino, Sandra N. Pinto, Ricardo Mendonça, Pedro M. P. Góis
Abstract
The site-selective chemical appendage of multiple functionalities on a native peptide backbone is a highly demanding and complex tool of modern chemical biology. Here, novel NHS-activated acrylates were designed to hold various payloads in a single bioconjugation handle that is able to site-selectively and orthogonally target the N-terminal cysteine of peptides.
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