Phosphine-mediated three-component bioconjugation of amino- and azidosaccharides in ionic liquids
Chemical Communications2022Vol. 58(75), pp. 10568–10571
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Yvonne Hall, Chiamaka Peace Uzoewulu, Zeinab M. Nizam, Seiya Ishizawa, Hisham M. El‐Shaffey, Jun Ohata
Abstract
Bioconjugation of carbohydrates has been a challenging task because of their chemical, functional, and structural diversities, and no single chemical modification tool can be universally applicable to all the target substrates in different environments. In this report, we have developed a bioconjugation strategy for labeling of carbohydrate derivatives through a phosphine-mediated three-component coupling reaction in an ionic liquid medium.
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