Quercetin ameliorated cardiac injury via reducing inflammatory actions and the glycerophospholipid metabolism dysregulation in a diabetic cardiomyopathy mouse model
Food & Function2022Vol. 13(14), pp. 7847–7856
Citations Over TimeTop 10% of 2022 papers
Chunjie Jiang, Dan Li, Li Chen, Yang Liu, Ying Zhao, Guibin Mei, Yuhan Tang, Yuexin Yang, Ping Yao, Chao Gao
Abstract
Quercetin has multiple protective effects against cardiometabolic diseases, but the biological mechanisms underlying the benefits in diabetic cardiomyopathy (DCM) are unclear. A mouse DCM model was established by high-fat diet (HFD, 8 months) combined with streptozotocin injection (at the mid-feeding), and quercetin (100 mg per kg per day) was administrated orally after streptozotocin. Our major results indicated that the cardiac ejection fraction and fractional shortening, mRNA levels of Collagen I and CTGF, and the protein expression levels of NLRP3, caspase-1, IL-1β, and IL-18 were reduced (P via reducing inflammatory actions and the glycerophospholipid metabolism dysregulation in DCM.
Related Papers
- → The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts(2008)101 cited
- → Connective tissue growth factor: a crucial cytokine-mediating cardiac fibrosis in ongoing enterovirus myocarditis(2007)81 cited
- → Inhibition of miR‐21 alleviated cardiac perivascular fibrosis via repressing EndMT in T1DM(2019)61 cited
- → EGCG inhibits CTGF expression via blocking NF-κB activation in cardiac fibroblast(2012)50 cited
- → MicroRNA-19 upregulation attenuates cardiac fibrosis via targeting connective tissue growth factor(2022)8 cited