Engineering ketoreductases for the enantioselective synthesis of chiral alcohols
Chemical Communications2023Vol. 59(49), pp. 7518–7533
Citations Over TimeTop 10% of 2023 papers
Abstract
The use of engineered ketoreductases (KREDS), both as whole microbial cells and isolated enzymes, in the highly enantiospecific reduction of prochiral ketones is reviewed. The homochiral alcohol products are key intermediates in, for example, pharmaceuticals synthesis. The application of sophisticated protein engineering and enzyme immobilisation techniques to increase industrial viability are discussed.
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