Frontiers in nonviral delivery of small molecule and genetic drugs, driven by polymer chemistry and machine learning for materials informatics

Citations Over TimeTop 18% of 2023 papers

Abstract

Materials informatics (MI) has immense potential to accelerate the pace of innovation and new product development in biotechnology. Close collaborations between skilled physical and life scientists with data scientists are being established in pursuit of leveraging MI tools in automation and artificial intelligence (AI) to predict material properties in vitro and in vivo. However, the scarcity of large, standardized, and labeled materials data for connecting structure-function relationships represents one of the largest hurdles to overcome. In this Highlight, focus is brought to emerging developments in polymer-based therapeutic delivery platforms, where teams generate large experimental datasets around specific therapeutics and successfully establish a design-to-deployment cycle of specialized nanocarriers. Three select collaborations demonstrate how custom-built polymers protect and deliver small molecules, nucleic acids, and proteins, representing ideal use-cases for machine learning to understand how molecular-level interactions impact drug stabilization and release. We conclude with our perspectives on how MI innovations in automation efficiencies and digitalization of data-coupled with fundamental insight and creativity from the polymer science community-can accelerate translation of more gene therapies into lifesaving medicines.

Related Papers

• → Pace: A Test of Authorship Based on the Rate at which New Words Enter an Author's Text(1988)17 cited
• Keeping Pace with the Time, Rnew the Work of Tought and Politi for Quitting and Retiring(2003)
• On the Nature of Marxist "Keeping Pace with the Times(2003)
• The Viewof Keeping Pace with the Times Developing Marxism(2003)
• Thoughts of Cadres of Colleges and Universities Should Keep Pace with the Times(2002)