Biomaterials with cancer cell-specific cytotoxicity: challenges and perspectives
Citations Over TimeTop 10% of 2024 papers
Abstract
Significant advances have been made in materials for biomedical applications, including tissue engineering, bioimaging, cancer treatment, etc. In the past few decades, nanostructure-mediated therapeutic strategies have been developed to improve drug delivery, targeted therapy, and diagnosis, maximizing therapeutic effectiveness while reducing systemic toxicity and side effects by exploiting the complicated interactions between the materials and the cell and tissue microenvironments. This review briefly introduces the differences between the cells and tissues of tumour or normal cells. We summarize recent advances in tumour microenvironment-mediated therapeutic strategies using nanostructured materials. We then comprehensively discuss strategies for fabricating nanostructures with cancer cell-specific cytotoxicity by precisely controlling their composition, particle size, shape, structure, surface functionalization, and external energy stimulation. Finally, we present perspectives on the challenges and future opportunities of nanotechnology-based toxicity strategies in tumour therapy.
Related Papers
- → Amyloid β cytotoxicity is enhanced or reduced depending on formation of amyloid β oligomeric forms(2020)8 cited
- Cytotoxicity test of medical device with silver nanoparticles(2010)
- → Interferon and spontaneous cytotoxicity in man. V. Enhancement of spontaneous cytotoxicity in patients receiving human leukocyte interferon(1980)77 cited
- Protective effect of Cynomorii Herba extract on $H_2O_2$-induced cytotoxicity(2004)
- Synthesis and antitumor activity of aza-chalcones and their Pt(IV) complexes(2011)