A sulfonated supramolecular host based on pillar[5]arene for succinylcholine-induced neuromuscular blockade reversal
Chemical Communications2025Vol. 61(32), pp. 5982–5985
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Abstract
A per-sulfonated pillar[5]arene (SP[5]A) is designed as a reversal agent to reverse neuromuscular blockade induced by succinylcholine (Sch) via host-guest recognition. SP[5]A can rapidly and specifically recognize and encapsulate Sch in vivo for elimination with a binding affinity as high as 105 M-1. SP[5]A mitigates Sch-induced adverse reactions including hyperkalemia, arrhythmias, and rhabdomyolysis.
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