SABRE-SHEATH hyperpolarized 15 N 2 -imidazole for Zn 2+ sensing
Chemical Communications2025Vol. 61(65), pp. 12115–12118
Citations Over TimeTop 12% of 2025 papers
Brojo Kishor Shachib Dhali, Abubakar Abdurraheem, Mustapha Abdulmojeed, Anna Samoilenko, Megan Pike, R. Harrison, Franziska Theiß, Boyd M. Goodson, Eduard Y. Chekmenev, Thomas Theis
Abstract
Zinc ions are essential for numerous biological functions and activities. Accordingly, Zn2+ sensors are crucial in biomedical research to understand the role of Zn2+ in health and disease. Here, we demonstrated the viability of SABRE-SHEATH hyperpolarized 15N2-imidazole, providing an NMR signal enhancement of 45 700 fold (p = 2.15%), as a probe for Zn2+ sensing by monitoring the Zn-imidazole interaction using NMR and extracted a LOD of 1.3 mM. This study is one of the first demonstrations of SABRE-SHEATH hyperpolarized 15N as a sensor of other non-hyperpolarized species, which promises chemical sensing without penetration-depth limitations.
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