A fluorogenic probe for screening aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors
Chemical Communications2025Vol. 61(82), pp. 16070–16073
Shilpendu Ghosh, S. Ghosh, Aniket Majee, Soumee SenGupta, S Mukherjee, Bidhan C. Roy, Rahul Das, Arindam Mukherjee
Abstract
We report the first competitive aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor featuring a fluorogenic binding response and nanomolar affinity (KD), enabling real-time screening of non-fluorescent inhibitors with high cellular compatibility and no observed toxicity.