Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis
New England Journal of Medicine2006Vol. 354(8), pp. 795–808
Citations Over TimeTop 1% of 2006 papers
Daniel O. Clegg, Domenic J. Reda, Crystal L. Harris, Marguerite Klein, James R. O’Dell, Michele Hooper, John Bradley, Clifton O. Bingham, Michael H. Weisman, Christopher Jackson, Nancy E. Lane, John J. Cush, Larry W. Moreland, H. Ralph Schumacher, Chester V. Oddis, Frederick Wolfe, Jerry A. Molitor, David E. Yocum, Thomas J. Schnitzer, Daniel E. Furst, Allen D. Sawitzke, Helen Shi, Kenneth D. Brandt, Roland W. Moskowitz, H. James Williams
Abstract
Glucosamine and chondroitin sulfate alone or in combination did not reduce pain effectively in the overall group of patients with osteoarthritis of the knee. Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain. (ClinicalTrials.gov number, NCT00032890.).
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