Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration
New England Journal of Medicine2008Vol. 359(14), pp. 1456–1463
Citations Over TimeTop 1% of 2008 papers
Zhenglin Yang, Charity A. Stratton, Peter J. Francis, Mark E. Kleinman, Perciliz L. Tan, Daniel Gibbs, Zongzhong Tong, Haoyu Chen, Ryan Constantine, Xian Yang, Yuhong Chen, Jiexi Zeng, Lisa Davey, Xiang Ma, Vincent Hau, Chi Wang, Jennifer N. Harmon, Jeanette Buehler, Erik Pearson, Shrena Patel, Yuuki Kaminoh, Scott Watkins, Ling Luo, Norman A. Zabriskie, Paul S. Bernstein, Won Gil Cho, A Schwager, David R. Hinton, Michael L. Klein, Sara Hamon, Emily Simmons, Beifeng Yu, Betsy Campochiaro, Janet S. Sunness, Peter A. Campochiaro, Lynn B. Jorde, Giovanni Parmigiani, Donald J. Zack, Nicholas Katsanis, Jayakrishna Ambati, Kang Zhang
Abstract
The TLR3 412Phe variant confers protection against geographic atrophy, probably by suppressing the death of retinal pigment epithelial cells. Since double-stranded RNA (dsRNA) can activate TLR3-mediated apoptosis, our results suggest a role of viral dsRNA in the development of geographic atrophy and point to the potential toxic effects of short-interfering-RNA therapies in the eye.
Related Papers
- → Research the most frequent localization of choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD)(2020)1 cited
- → 585Radiation therapy for choroidal neovascularization (CNV) in age-related macular degeneration (AMD) (preliminary results)(1996)
- Risk factors for choroidal neovascularization (CNV) in the second eye of patients with age-related macular degeneration (AMD)(1997)
- Comparison Of Anti-mt1-mmp And Anti-vegf Therapy In Age-related Macular Degeneration (amd) Choroidal Neovascularization (cnv) Model(2011)
- Effect of Quercetin on Formation of Choroidal Neovascularization （CNV） in Age-related Macular Degeneration （AMD）(2011)