Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
New England Journal of Medicine2008Vol. 359(13), pp. 1317–1329
Citations Over TimeTop 1% of 2008 papers
Werner Hacke, Markku Kaste, Erich Bluhmki, M Brozman, Antoni Dávalos, Donata Guidetti, Vincent Larrue, Kennedy R. Lees, Zakaria Medeghri, Thomas Machnig, Dietmar Schneider, Rüdiger von Kummer, Nils Wahlgren, Danilo Toni
Abstract
As compared with placebo, intravenous alteplase administered between 3 and 4.5 hours after the onset of symptoms significantly improved clinical outcomes in patients with acute ischemic stroke; alteplase was more frequently associated with symptomatic intracranial hemorrhage. (ClinicalTrials.gov number, NCT00153036.)
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