Recurrent SomaticDICER1Mutations in Nonepithelial Ovarian Cancers
New England Journal of Medicine2011Vol. 366(3), pp. 234–242
Citations Over TimeTop 1% of 2011 papers
Alireza Heravi‐Moussavi, Michael S. Anglesio, Siwei Cheng, Janine Senz, Winnie Yang, Leah Prentice, Anthony P. Fejes, Christine Chow, Alicia Tone, Steve E. Kalloger, Nancy Hamel, Andrew Roth, Gavin Ha, Adrian Wan, Sarah Maines‐Bandiera, Clara Salamanca, Barbara Pasini, Blaise Clarke, Anna F. Lee, Cheng‐Han Lee, Chengquan Zhao, Robert H. Young, Samuel Aparício, Poul H. Sorensen, Michelle M.M. Woo, Niki Boyd, Steven J.M. Jones, Martin Hirst, Marco A. Marra, C. Blake Gilks, Sohrab P. Shah, William D. Foulkes, Gregg B. Morin, David G. Huntsman
Abstract
Somatic missense mutations affecting the RNase IIIb domain of DICER1 are common in nonepithelial ovarian tumors. These mutations do not obliterate DICER1 function but alter it in specific cell types, a novel mechanism through which perturbation of microRNA processing may be oncogenic. (Funded by the Terry Fox Research Institute and others.).
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