Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer
New England Journal of Medicine2013Vol. 368(11), pp. 987–998
Citations Over TimeTop 1% of 2013 papers
Sarah C. Darby, Marianne Ewertz, Paul McGale, Anna M. Bennet, U. Blom-Goldman, Dorthe Brønnum, Candace R. Correa, David J. Cutter, Giovanna Gagliardi, Bruna Gigante, Maj‐Britt Jensen, A. Nisbet, Richárd Pető, Kazem Rahimi, Carolyn Taylor, Per Hall
Abstract
Exposure of the heart to ionizing radiation during radiotherapy for breast cancer increases the subsequent rate of ischemic heart disease. The increase is proportional to the mean dose to the heart, begins within a few years after exposure, and continues for at least 20 years. Women with preexisting cardiac risk factors have greater absolute increases in risk from radiotherapy than other women. (Funded by Cancer Research UK and others.).
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