Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
New England Journal of Medicine2014Vol. 371(5), pp. 411–423
Citations Over TimeTop 1% of 2014 papers
Elizabeth A. Ashley, Mehul Dhorda, Rick M. Fairhurst, Chanaki Amaratunga, Pharath Lim, Seila Suon, Sokunthea Sreng, Jennifer M. Anderson, Sivanna Mao, Baramey Sam, Chantha Sopha, Char Meng Chuor, Chea Nguon, Siv Sovannaroth, Sasithon Pukrittayakamee, Podjanee Jittamala, Kesinee Chotivanich, Kitipumi Chutasmit, Chaiyaporn Suchatsoonthorn, Ratchadaporn Runcharoen, Tran Tinh Hien, Thuy-Nhien Nguyen, Ngo Viet Thanh, Nguyen Hoan Phu, Ye Htut, Kay-Thwe Han, Kyin Hla Aye, Olugbenga Ayodeji Mokuolu, Rasaq Olaosebikan, Olaleke Oluwasegun Folaranmi, Mayfong Mayxay, Maniphone Khanthavong, Bouasy Hongvanthong, Paul N. Newton, Marie Onyamboko, Caterina Fanello, Antoinette Tshefu, Neelima Mishra, Neena Valecha, Aung Pyae Phyo, François Nosten, Poravuth Yi, Rupam Tripura, Steffen Borrmann, Mahfudh M. Bashraheil, Judy Peshu, Maryam Faiz, Aniruddha Ghose, Md. Amir Hossain, Rasheda Samad, Mizanur Rahman, M. Mahtabuddin Hasan, Akhterul Islam, Olivo Miotto, Roberto Amato, Bronwyn MacInnis, Jim Stalker, Dominic Kwiatkowski, Zbynek Bozdech, Atthanee Jeeyapant, Phaik Yeong Cheah, Tharisara Sakulthaew, Jeremy Chalk, Benjamas Intharabut, Kamolrat Silamut, Sue J. Lee, Benchawan Vihokhern, Chanon Kunasol, Mallika Imwong, Joel Tärning, Walter J. Taylor, Shunmay Yeung, Charles J. Woodrow, Jennifer A. Flegg, Debashish Das, Jeffery Smith, Meera Venkatesan, Christopher V. Plowe, Kasia Stepniewska, Philippe J. Guérin, Arjen M. Dondorp, Nicholas Day, Nicholas J. White
Abstract
Artemisinin resistance to P. falciparum, which is now prevalent across mainland Southeast Asia, is associated with mutations in kelch13. Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing. (Funded by the U.K. Department of International Development and others; ClinicalTrials.gov number, NCT01350856.).
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