Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke
New England Journal of Medicine2017Vol. 377(11), pp. 1011–1021
Citations Over TimeTop 1% of 2017 papers
Jean‐Louis Mas, Geneviève Dérumeaux, B. Guillon, Evelyne Massardier, Hassan Hosseini, Laura Mechtouff, Caroline Arquizan, Yannick Béjot, Fabrice Vuillier, Olivier Detante, Céline Guidoux, Sandrine Canaple, Claudia Vaduva, Nelly Dequatre‐Ponchelle, Igor Sibon, Pierre Garnier, Anna Ferrier, Serge Timsit, Emmanuelle Robinet-Borgomano, Denis Sablot, Jean‐Christophe Lacour, Mathieu Zuber, Pascal Favrole, Jean‐François Pinel, Marion Apoil, Peggy Reiner, Catherine Lefebvre, Patrice Guérin, Christophe Piot, Roland Rossi, Jean‐Luc Dubois‐Randé, Jean‐Christophe Eicher, Nicolas Piriou, Jean‐René Lusson, Bernard Bertrand, Jean‐Marc Schleich, François Godart, Jean‐Benoît Thambo, Laurent Leborgne, Patrik Michel, Luc Piérard, Guillaume Turc, Martine Barthelet, Anaïs Charles‐Nelson, Christian Weimar, Thierry Moulin, Jean‐Michel Juliard, Gilles Châtellier
Abstract
Among patients who had had a recent cryptogenic stroke attributed to PFO with an associated atrial septal aneurysm or large interatrial shunt, the rate of stroke recurrence was lower among those assigned to PFO closure combined with antiplatelet therapy than among those assigned to antiplatelet therapy alone. PFO closure was associated with an increased risk of atrial fibrillation. (Funded by the French Ministry of Health; CLOSE ClinicalTrials.gov number, NCT00562289 .).
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