Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis
New England Journal of Medicine2021Vol. 384(15), pp. 1424–1436
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Christopher G. Hughes, Patrick Mailloux, John W. Devlin, Joshua T. Swan, Robert D. Sanders, Antonio Anzueto, James C. Jackson, Aimee S. Hoskins, Brenda T. Pun, Onur M Orun, Rameela Raman, Joanna L. Stollings, Amy L. Kiehl, Matthew S. Duprey, Lan N. Bui, Hollis R. O’Neal, Allison Snyder, Michael A. Gropper, Kalpalatha K. Guntupalli, Gregg J. Stashenko, Mayur B. Patel, Nathan E. Brummel, Timothy D. Girard, Robert S. Dittus, Gordon R. Bernard, E. Wesley Ely, Pratik P. Pandharipande
Abstract
Among mechanically ventilated adults with sepsis who were being treated with recommended light-sedation approaches, outcomes in patients who received dexmedetomidine did not differ from outcomes in those who received propofol. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT01739933.).
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