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Biocatalysis for Sustainable Organic Synthesis
Australian Journal of Chemistry2004Vol. 57(4), pp. 281–289
Citations Over TimeTop 17% of 2004 papers
Abstract
Biocatalysis offers mild reaction conditions, an environmentally attractive catalyst–solvent system, high activities, and chemo-, regio-, and stereoselectivities, while the use of enzymes generally circumvents the need for functional group activation and avoids protection/deprotection steps required in traditional organic syntheses. This review, using ß-lactam antibiotics as an example, discusses recent advances in biocatalysis research towards the goal of ‘green’ methodologies for the manufacture of (fine) chemicals and the emulation of a cell's enzymatic cascade processes.
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