A High Relaxivity Magnetic Resonance Imaging Contrast Agent Targeted to Serum Albumin
Australian Journal of Chemistry2008Vol. 61(9), pp. 682–686
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Stéphane Dumas, Jeffrey S. Troughton, Normand J. Cloutier, Jaclyn M. Chasse, Thomas J. McMurry, Peter Caravan
Abstract
EP-647 is a serum albumin-targeted magnetic resonance imaging contrast agent comprising a GdDTPA (DTPA, diethylenetriaminepentaacetate) chelate for magnetic resonance signal generation linked via a phosphodiester to a substituted biphenyl for albumin targeting. Albumin binding and relaxivity are higher than the benchmark magnetic resonance angiographic agent MS-325. EP-647 binds primarily to a unique site on serum albumin that is different from the MS-325 site and the binding sites of other drugs.
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