Anticancer Evaluation of Tris(triazolyl)triazine Derivatives Generated via Click Chemistry

Citations Over TimeTop 14% of 2016 papers

Abstract

Click chemistry has been utilised for the preparation of new tris(triazolyl)triazines containing aliphatic and polar side chains through coupling of 2,4,6-triethynyl-[1,3,5]triazines, which possess free terminal alkyne moieties with substituted aromatic azides. The cytotoxic activity and in vitro anticancer potential of the newly synthesised compounds have been evaluated against seven human cancer cell lines including liver HepG2, breast MCF-7, lung A549, acute myeloid leukemia HL-60, colon HCT116, and prostate PC3 cancer cell lines in addition to human normal melanocyte, HFB4. The results revealed that all the compounds did not exhibit any activity against A549, HL-60, and PC3. However compound G2 was effective against MCF-7 and HepG2 cancer cell lines. On the other hand, compound G1a exhibited higher potency against MCF-7 and HepG2 cells with no toxicity on normal cells in comparison with the standard drug doxorubicin.

Related Papers

• → Click Chemistry for Rapid Labeling and Ligation of RNA(2010)178 cited
• → Tris(hydroxymethyl)aminomethane buffer modification of Escherichia coli outer membrane permeability(1981)124 cited
• → Syntheses and structures of tris(para-tolyl)-, tris(3-fluorophenyl)-, and tris(4-fluorophenyl)antimony dioximates(2017)8 cited
• → Certain reactions of tris(?,?,?-trihydroperfluoroalkyl) phosphites(1979)2 cited
• → ChemInform Abstract: TRIS(HYDROXYMETHYL)AMINOMETHANE (TRIS) BUFFER AND AMINO ACID ANALYSIS(1974)