Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
Proceedings of the National Academy of Sciences1996Vol. 93(6), pp. 2576–2581
Citations Over TimeTop 1% of 1996 papers
Berit Olofsson, Katri Pajusola, Arja Kaipainen, Gabriel von Euler, Vladimir Joukov, Olli Saksela, Arto Orpana, Ralf F. Pettersson, Kari Alitalo, Ulf Eriksson
Abstract
We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.
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