Carcinoma in situ in the Testis
Scandinavian Journal of Urology and Nephrology2000Vol. 34(205), pp. 166–186
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Mikael Rørth, Ewa Rajpert‐De Meyts, Lennart Andersson, Klaus‐Peter Dieckmann, Sophie D. Fosså, Kenneth M. Grigor, W. F. HENDRY, Harry W. Herr, Leendert H. J. Looijenga, J. Wolter Oosterhuis, Niels E. Skakkebæk
Abstract
Carcinoma in situ (CIS) of the testis is a common precursor of germ-cell tumours in adults and adolescents, with the exception of spermatocytic seminoma. This article reviews existing knowledge on the pathobiology, genetic aspects and epidemiology of CIS, discusses current hypotheses concerning pathogenesis and invasive progression of germ-cell neoplasms and provides guidelines for diagnosis and clinical management of CIS.
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