Early Immune Activation in Acute Dengue Illness Is Related to Development of Plasma Leakage and Disease Severity

Citations Over TimeTop 1% of 1999 papers

Abstract

T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with <72 h of fever were studied. Plasma levels of 80-kDa soluble tumor necrosis factor receptors (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-gamma and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-alpha was detectable more often in DHF than in DF or OFIs (P<.05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.

Related Papers

• → An evaluation of the World Health Organization’s 1997 and 2009 dengue classifications in hospitalized dengue patients in Malaysia(2014)14 cited
• To assess the severity of dengue fever in patients attending a tertiary careteaching hospital using WHO grading system(2013)
• → Utility of dengue antigen-capture ELISA in the diagnosis of dengue Fever in the real world(2010)1 cited
• Dengue Score A Simple and Highly Specific Test for Diagnosis of Dengue Infection in Resource-limited Settings--Dengue Score การวนจฉยโรคตดเชอไวรสเดงกอยางงายและแมนยำในประเทศทมทรพยากรจำกด(2018)
• → CORRELATION OF DENGUE SCORE WITH THE SEVERITY OF DENGUE(2023)