Loss of CD4+T Cell Proliferative Ability but Not Loss of Human Immunodeficiency Virus Type 1 Specificity Equates with Progression to Disease

Citations Over TimeTop 10% of 2000 papers

Abstract

In this study, we compared human immunodeficiency virus (HIV) type 1-specific proliferative responses with HIV-1-induced intracellular cytokine production in a cohort of clinically nonprogressing patients and individuals with progressive HIV-1 infection. We found strong HIV-1-specific proliferative responses in the clinical nonprogressor cohort that correlated with significant numbers of circulating HIV-1-specific CD4(+) T cells. In contrast, HIV-1-specific proliferative responses were absent in most individuals with progressive HIV-1 infection, even though interferon-gamma-producing HIV-1-specific CD4(+) T cells were detectable by flow cytometry. The implication of these data is that the important dysfunction seen in most HIV-positive patients from very early in disease may be an inability of HIV-1-specific CD4(+) memory T cells to proliferate in response to HIV antigens rather than an absolute loss of circulating virus-specific CD4(+) T cells.

Related Papers

• → Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza(2014)75 cited
• → X-linked lymphoproliferative disease (XLP) as a model of Epstein-Barr virus-induced immunopathology(1991)32 cited
• → Immunopathology and pathogenesis of human immunodeficiency virus infection(1991)14 cited
• → VIRAL IMMUNOPATHOLOGY(1985)22 cited
• [HIV infection. Immunopathology and pathogenesis].(1991)