High‐Level Chloroquine Resistance in Sudanese Isolates ofPlasmodium falciparumIs Associated with Mutations in the Chloroquine Resistance Transporter Genepfcrtand the Multidrug Resistance Genepfmdr1
The Journal of Infectious Diseases2001Vol. 183(10), pp. 1535–1538
Citations Over TimeTop 1% of 2001 papers
Hamza A. Babiker, S. J. Pringle, Abdel-Muhsin A. Abdel-Muhsin, Margaret J. Mackinnon, Patrick J. Hunt, David Walliker
Abstract
Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance gene pfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance.
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