Granulysin‐Dependent Killing of Intracellular and ExtracellularMycobacterium tuberculosisby Vγ9/Vδ2 T Lymphocytes
The Journal of Infectious Diseases2001Vol. 184(8), pp. 1082–1085
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Francesco Dieli, Marita Troye‐Blomberg, Juraj Iványi, Jean‐Jacques Fournié, Alan M. Krensky, Marc Bonneville, Marie Alix Peyrat, Nadia Caccamo, Guido Sireci, Alfredo Salerno
Abstract
Contribution of Vgamma9/Vdelta2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vgamma9/Vdelta2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vgamma9/Vdelta2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vgamma9/Vdelta2 T lymphocytes, play a major role, which indicates that Vgamma9/Vdelta2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.
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