Absolute Levels and Ratios of Proinflammatory and Anti‐inflammatory Cytokine Production In Vitro Predict Clinical Immunity toPlasmodium falciparumMalaria

Citations Over TimeTop 1% of 2002 papers

Abstract

The relationship between malaria-related outcomes and cytokine production in whole blood cultures associated with cellular immune responses and immunity to Plasmodium falciparum malaria was examined in a study in southern Ghana. Production of malaria-specific interferon (IFN)-gamma was associated with reduced risk of fever and clinical malaria. Protective IFN-gamma responses were induced by live schizonts but not by dead parasites. Production of malaria-specific tumor necrosis factor (TNF)-alpha was associated with reduced risk of fever during follow-up. Baseline levels of TNF-alpha and phytohemagglutinin (PHA)-induced interleukin (IL)-10 were positively associated with hemoglobin concentration. IL-12 production was associated with reduced risk of parasitemia. PHA-induced transforming growth factor-beta production was associated with reduced risk of fever during follow-up. High ratios of proinflammatory to anti-inflammatory cytokines were associated with increased risk of fever and higher hemoglobin concentrations. Thus, absolute levels and ratios of proinflammatory and anti-inflammatory cytokines influence susceptibility to infection, clinical disease, and anemia. These data contradict data from cross-sectional clinical studies and indicate a need for detailed analysis of the relationship between cellular immunity to malaria and resistance to disease.

Related Papers

• → Changing Malaria Epidemiology and Diagnostic Criteria for Plasmodium falciparum Clinical Malaria(2012)70 cited
• → Different forms of administration of biotherapy 7dH in mice experimentally infected by Trypanosoma cruzi produce different effects(2011)26 cited
• → Evaluation of the Accuracy of the EasyTest™ Malaria Pf/Pan Ag, a Rapid Diagnostic Test, in Uganda(2014)14 cited
• → In Vitro Cultivation of Plasmodium Falciparum at High Parasitemia(1974)12 cited
• Prevalence of Malaria Parasitaemia among Children Resident in Orphanages in Anambra State, Nigeria(2017)