Management of Rabies in Humans
Clinical Infectious Diseases2003Vol. 36(1), pp. 60–63
Citations Over TimeTop 10% of 2003 papers
Alan C. Jackson, Mary Warrell, Charles E. Rupprecht, Hildegund C.J. Ertl, Bernhard Dietzschold, Michael O’Reilly, Richard P. Leach, Zhen F. Fu, William H. Wunner, Thomas P. Bleck, Henry Wilde
Abstract
Rabies is a fatal disease in humans, and, to date, the only survivors of the disease have received rabies vaccine before the onset of illness. The approach to management of the rabies normally should be palliative. In unusual circumstances, a decision may be made to use an aggressive approach to therapy for patients who present at an early stage of clinical disease. No single therapeutic agent is likely to be effective, but a combination of specific therapies could be considered, including rabies vaccine, rabies immunoglobulin, monoclonal antibodies, ribavirin, interferon-alpha, and ketamine. Corticosteroids should not be used. As research advances, new agents may become available in the future for the treatment of human rabies.
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