Use of the Quorum‐Sensing Inhibitor RNAIII‐Inhibiting Peptide to Prevent Biofilm Formation In Vivo by Drug‐ResistantStaphylococcus epidermidis
Citations Over TimeTop 10% of 2003 papers
Abstract
Staphylococcus epidermidis is a frequent cause of infections associated with foreign bodies and indwelling medical devices. The bacteria are capable of surviving antibiotic treatment through encapsulation into biofilms. RNAIII-inhibiting peptide (RIP) is a heptapeptide that inhibits S. aureus pathogenesis by disrupting quorum-sensing mechanisms. In this study, RIP inhibited drug-resistant S. epidermidis biofilm formation through a mechanism similar to that evidenced for S. aureus. RIP is synergistic with antibiotics in eliminating 100% of graft-associated in vivo S. epidermidis infections, which suggests that RIP may be used to coat medical devices to prevent staphylococcal infections. Disruption of cell-cell communication can prevent infections associated with antibiotic-resistant strains.
Related Papers
- → Biofilm dispersion and quorum sensing(2014)605 cited
- → Is there a role for quorum sensing signals in bacterial biofilms?(2002)257 cited
- → Estimation of spatial distribution of quorum sensing signaling in sequencing batch biofilm reactor (SBBR) biofilms(2017)55 cited
- Quorum Sensing Signal Molecule and Biofilm-forming Capacity in Coastal Bacteria(2010)
- → Faculty Opinions recommendation of Is there a role for quorum sensing signals in bacterial biofilms?(2002)