Age‐Related Immune Dysfunction in Health and in Human Immunodeficiency Virus (HIV) Disease: Association of Age and HIV Infection with Naive CD8+Cell Depletion, Reduced Expression of CD28 on CD8+Cells, and Reduced Thymic Volumes

Citations Over TimeTop 17% of 2003 papers

Abstract

Older age is a strong predictor of accelerated human immunodeficiency virus (HIV) disease progression. We investigated the possible immunologic basis of this interaction by comparing older (>/=45 years) and younger (</=30 years) HIV-infected adults with simultaneously enrolled, aged-matched, healthy volunteers. Cross-sectional comparisons suggested age-associated reductions in naive CD8(+) cells and in the expression of CD28(+) on CD8(+) cells among both HIV-infected subjects and control subjects. Opposite patterns of CD4(+) and CD8(+) cell differences were apparent between these subject groups. HIV infection, but not age, was associated with impairments in delayed-type hypersensitivity responses, lymphoproliferation, and spontaneous apoptosis and with alterations in expression of chemokine receptors CCR5 and CXCR4. Reduced thymic volumes were associated with age and with HIV infection among younger, but not older, subjects. Because of their common association with age and HIV disease, naive CD8(+) cell depletion, diminished CD28 expression on CD8(+) cells, and reduced thymic volumes are possible correlates of the interaction of age with HIV disease.

Related Papers

• → Absence of B7-dependent responses in CD28-deficient mice(1994)377 cited
• → Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28- T cells(1997)76 cited
• → Synergy between CD28 and CD9 costimulation for naive T-cell activation(1997)14 cited
• → CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase(1995)62 cited
• → Generation of CD28− cells from long-term-stimulated CD8+CD28+ T cells: a possible mechanism accounting for the increased number of CD8+CD28− T cells in HIV-1-infected patients(1999)25 cited