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Treatment Outcomes for Serious Infections Caused by Methicillin‐ResistantStaphylococcus aureuswith Reduced Vancomycin Susceptibility

Clinical Infectious Diseases2004Vol. 38(4), pp. 521–528

Citations Over TimeTop 1% of 2004 papers

Benjamin P. Howden, Peter Ward, Patrick G. P. Charles, Tony M. Korman, Andrew Fuller, Philipp du Cros, Elizabeth A. Grabsch, Sally Roberts, Jenny Robson, Kerry Read, Narin Bak, James C. Hurley, Paul D. R. Johnson, Arthur J. Morris, Barrie C. Mayall, M. Lindsay Grayson

Abstract

Although infections caused by methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility (SA-RVS) have been reported from a number of countries, including Australia, the optimal therapy is unknown. We reviewed the clinical features, therapy, and outcome of 25 patients with serious infections due to SA-RVS in Australia and New Zealand. Eight patients had endocarditis, 9 had bacteremia associated with deep-seated infection, 6 had osteomyelitis or septic arthritis, and 2 had empyema. All patients had received vancomycin before the isolation of SA-RVS, and glycopeptide treatment had failed for 19 patients (76%). Twenty-one patients subsequently received active treatment, which was effective for 16 patients (76%). Eighteen patients received linezolid, which was effective in 14 (78%), including 4 patients with endocarditis. Twelve patients received a combination of rifampicin and fusidic acid. Surgical intervention was required for 15 patients (60%). Antibiotic therapy, especially linezolid with or without rifampicin and fusidic acid, in conjunction with surgical debulking is effective therapy for the majority of patients with serious infections (including endocarditis) caused by SA-RVS.

Citations Over TimeTop 1% of 2004 papers

Abstract

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