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Two Subtypes of Genotype B (Ba and Bj) of Hepatitis B Virus in Japan

Clinical Infectious Diseases2004Vol. 38(9), pp. 1222–1228

Citations Over TimeTop 10% of 2004 papers

Fuminaka Sugauchi, H Kumada, Hiroshi Sakugawa, Masashi Komatsu, Hiroaki Niitsuma, Hisayoshi Watanabe, Y. Akahane, Hajime Tokita, Takanobu Kato, Yasuhito Tanaka, Etsuro Orito, Ryuzo Ueda, Y. Miyakawa, M Mizokami

Abstract

We have previously reported 2 subtypes of hepatitis B virus (HBV) genotype B, one of which has the recombination with genotype C over the precore region plus core gene (Ba) and the other of which does not (Bj). A restriction fragment-length polymorphism method with 2 endonucleases was newly developed for distinguishing between subtypes Ba and Bj and was applied to 313 carriers of HBV genotype B in Japan. Subtype Ba was detected in 38 (12%) and subtype Bj in 275 (88%) of the carriers of HBV genotype B. Hepatitis B e antigen in serum was found more frequently in patients with chronic infection with subtype Ba than in those with chronic infection with subtype Bj (8 [32%] of 25 vs. 25 [9%] of 273; P<.01). The new method for distinguishing between Ba and Bj by restriction fragment-length polymorphism would be useful in examining the distribution of these 2 subtypes in situations in which HBV genotype B is prevalent.

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