Size and Charge Characteristics of the Protein Leak in Dengue Shock Syndrome
The Journal of Infectious Diseases2004Vol. 190(4), pp. 810–818
Citations Over TimeTop 10% of 2004 papers
Bridget Wills, E. Oragui, Nguyen Minh Dung, Hà Thị Loan, Nguyen Vinh Chau, Jeremy Farrar, Michael Levin
Abstract
The endothelial size-dependent sieving mechanism for plasma proteins is at least partially retained, whereas selective restriction based on negative charge is impaired. The increased heparan sulfate excretion suggests a role for GAGs in the pathogenesis of the vascular leak.
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