Association between Vitamin D Receptor Gene Polymorphisms and Response to Treatment of Pulmonary Tuberculosis
The Journal of Infectious Diseases2004Vol. 190(5), pp. 920–927
Citations Over TimeTop 14% of 2004 papers
Daniel Roth, Giselle Soto, Fanny Arenas, Christian T. Bautista, Jaime Ortiz, Richard Rodríguez, Lilia Cabrera, Robert H. Gilman
Abstract
VDR gene polymorphisms are associated with the time to sputum culture and auramine stain conversion during TB treatment. To our knowledge, the present study is the first report of a specific host gene influence on the outcome of TB treatment. These findings demonstrate the potential clinical relevance of immunomodulatory functions of vitamin D metabolites acting via the VDR in the host response against pulmonary TB.
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