Quantitative Analysis of Epstein‐Barr Virus (EBV)–Specific CD8+T Cells in Patients with Chronic Active EBV Infection
Citations Over TimeTop 23% of 2004 papers
Abstract
To clarify the pathogenesis of chronic active Epstein-Barr virus (EBV) infection, EBV-specific CD8+ T cells were enumerated, by use of human leukocyte antigen (HLA)-A*2402-restricted tetramers, in 8 patients with chronic active EBV infection, 10 patients with infectious mononucleosis, and 16 EBV-seropositive healthy control subjects. In most of the patients with chronic active EBV infection, EBV-specific CD8+ T cells were not detected. Of note, latent membrane protein 2-specific CD8+ T cells were not detectable in any patients with chronic active EBV infection. In contrast, EBV-specific CD8+ T cells were detected in patients with infectious mononucleosis and in healthy control subjects. Low frequencies of EBV-specific CD8+ T cells may be one of the immunological features of chronic active EBV infection.
Related Papers
- → IMMUNOHISTOLOGY OF EPSTEIN-BARR VIRUS-ASSOCIATED ANTIGENS IN B CELL DISORDERS FROM IMMUNOCOMPROMISED INDIVIDUALS(1990)210 cited
- → Оptimization of Treatment EBV Infectious Mononucleosis in Children(2015)8 cited
- → B-cell lymphoproliferative disorders in solid-organ transplant patients: Detection of Epstein-Barr virus by in situ hybridization(1992)37 cited
- → Mononucleosis syndrome and coincidental human herpesvirus-7 and Epstein-Barr virus infection(1998)15 cited
- Acute cerebellar syndrome in infectious mononucleosis: documentation of two cases with Epstein-Barr virus infection.(1985)