Pharmacodynamics of Caspofungin in a Murine Model of Invasive Pulmonary Aspergillosis: Evidence of Concentration‐Dependent Activity
The Journal of Infectious Diseases2004Vol. 190(8), pp. 1464–1471
Citations Over TimeTop 10% of 2004 papers
Nathan P. Wiederhold, Dimitrios P. Kontoyiannis, Jingduan Chi, Randall A. Prince, Vincent H. Tam, Russell E. Lewis
Abstract
CAS demonstrates concentration-dependent pharmacodynamics in the treatment of IPA. The Cmax : MEC ratio appears to be the parameter most closely associated with the reduction of pulmonary fungal burden.
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