Determinants of Immune Reconstitution Inflammatory Syndrome in HIV Type 1–Infected Patients with Tuberculosis after Initiation of Antiretroviral Therapy
Clinical Infectious Diseases2004Vol. 39(11), pp. 1709–1712
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Guillaume Breton, Xavier Duval, Candice Estellat, Xavier Poaletti, D Bonnet, David Mvondo Mvondo, Pascale Longuet, Catherine Leport, Jean‐Louis Vildé
Abstract
Immune reconstitution inflammatory syndrome (IRIS) occurred in 16 of 37 antiretroviral-naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases in the CD4 cell percentage and in the ratio of CD4 cells to CD8 cells after 1 month of antiretroviral therapy and to dissemination of tuberculosis. These results have implications for the diagnosis of IRIS and the understanding of its pathogenesis.
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