Differences between T Cell–Type and Natural Killer Cell–Type Chronic Active Epstein‐Barr Virus Infection
Citations Over TimeTop 10% of 2005 papers
Abstract
Infections of T cells and natural killer (NK) cells play a central role in the pathogenesis of chronic active Epstein-Barr virus (CAEBV) infection. To characterize the virologic and cytokine profiles of T cell-type and NK cell-type infection, 39 patients with CAEBV infection were analyzed. Patients with T cell-type infection had higher titers of immunoglobulin G against early and late EBV antigens, suggesting lytic cycle infection. However, the pattern of EBV gene expression was latency type II; BZLF1, which is a hallmark of lytic cycle infection, could not be detected in any patients, regardless of infection type. Patients with CAEBV infection had high concentrations of proinflammatory, T helper cell type 1, and anti-inflammatory cytokines. The cytokine profile in patients with NK cell-type infection was similar to that in patients with T cell-type infection, but the concentration of IL-13 was high in patients with NK cell-type infection. These findings should help to clarify the pathogenesis of CAEBV infection and facilitate the development of more-effective treatments.
Related Papers
- → Lack of evidence for an involvement of Epstein-Barr virus infection of synovial membranes in the pathogenesis of rheumatoid arthritis(2000)43 cited
- → Radiation-induced Epstein–Barr virus reactivation in gastric cancer cells with latent EBV infection(2017)16 cited
- → Simian Haemorrhagic Fever (SHF): New Virus Isolate from a Chronically Infected Patas Monkey(1980)15 cited
- → Section Review Biologicals & Immunologicals: Deregulation of cytokine production in AIDS: implication for therapy(1995)
- → Inhibition of Epstein‐Barr Virus by an Atypical Antipsychotic(2018)