Development and Characterization of a Severe Acute Respiratory Syndrome–Associated Coronavirus–Neutralizing Human Monoclonal Antibody That Provides Effective Immunoprophylaxis in Mice
The Journal of Infectious Diseases2005Vol. 191(4), pp. 507–514
Citations Over TimeTop 10% of 2005 papers
Thomas C. Greenough, Gregory J. Babcock, Anjeanette Roberts, Héctor J. Hernández, William D. Thomas, Jennifer A. Coccia, Robert F. Graziano, M. S. Srinivasan, Israel Lowy, Robert W. Finberg, Kanta Subbarao, Leatrice Vogel, Mohan Somasundaran, Katherine Luzuriaga, John L. Sullivan, Donna M. Ambrosino
Abstract
Two neutralizing epitopes were defined for MAbs to SARS-CoV S glycoprotein. Antibodies to both epitopes protected mice against SARS-CoV challenge. Clinical trials are planned to test MAb 201, a fully human MAb specific for the epitope within the receptor-binding region.
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