GB Virus C Coinfection and HIV‐1 Disease Progression: The Amsterdam Cohort Study
The Journal of Infectious Diseases2005Vol. 191(5), pp. 678–685
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Akke K. van der Bij, Nico Kloosterboer, Maria Prins, Brigitte Boeser‐Nunnink, Ronald B. Geskus, Joep MA Lange, R A Coutinho, Hanneke Schuitemaker
Abstract
Rather than a positive effect of GBV-C RNA presence, a negative effect of GBV-C RNA loss on HIV-1 disease progression was found, which disappeared after adjustment for time-updated CD4(+) cell count. We therefore hypothesize that GBV-C RNA persistence depends on the presence of a sufficient number of CD4(+) cells--and that the CD4(+) cell decrease associated with HIV-1 disease progression is a cause, not a consequence, of GBV-C RNA loss.
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