Mucosal Lymphoid Infiltrate Dominates Colonic Pathological Changes in Murine Experimental Shigellosis
The Journal of Infectious Diseases2005Vol. 192(1), pp. 136–148
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Maria Celeste Martino, Giacomo Rossi, Irene Martini, Ivan Tattoli, Damiana Chiavolini, Armelle Phalipon, Philippe Sansonetti, Maria Lina Bernardini
Abstract
We provide a murine model in which shigellae are able to reach their natural tissue target: the colon. Moreover, the absence of polymorphonuclear leukocyte recruitment and of epithelial cell lesions reveal some aspects of shigellosis that are usually hidden by the prevalence of this cell population. This novel model may contribute to the identification of new targets for vaccines and therapies.
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