The Duration of Hypotension before the Initiation of Antibiotic Treatment Is a Critical Determinant of Survival in a Murine Model ofEscherichia coliSeptic Shock: Association with Serum Lactate and Inflammatory Cytokine Levels
The Journal of Infectious Diseases2005Vol. 193(2), pp. 251–258
Citations Over TimeTop 10% of 2005 papers
Anand Kumar, Cameron Haery, Bhanu Paladugu, Aseem Kumar, Simon Symeoneides, Leo Taiberg, Jailan Osman, Gordon M. Trenholme, Steven M. Opal, Roy D. Goldfarb, Joseph E. Parrillo
Abstract
The timing of antibiotic treatment relative to hypotension is closely associated with survival in this murine model of septic shock. Delay in antibiotic treatment results in the persistence of inflammatory/stress markers even after antibiotic treatment is initiated.
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