Effects of a Single Large Dose of Vitamin A, Given during the Postpartum Period to HIV‐Positive Women and Their Infants, on Child HIV Infection, HIV‐Free Survival, and Mortality
The Journal of Infectious Diseases2006Vol. 193(6), pp. 860–871
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Jean H Humphrey, Peter Iliff, Edmore Marinda, Kuda Mutasa, Lawrence H. Moulton, Henry Chidawanyika, Brian J. Ward, Kusum Nathoo, Lucie C. Malaba, Lynn S. Zijenah, P Zvandasara, Robert Ntozini, Faith Mzengeza, Agnes Mahomva, Andrea Ruff, Michael T. Mbizvo, Clare Zunguza, ZVITAMBO Study Group
Abstract
Targeted vitamin A supplementation of HIV-positive children prolongs their survival. However, postpartum maternal and neonatal vitamin A supplementation may hasten progression to death in breast-fed children who are PCR negative at 6 weeks. These findings raise concern about universal maternal or neonatal vitamin A supplementation in HIV-endemic areas.
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