Coinfection with Hepatitis C Virus Increases Lymphocyte Apoptosis in HIV-Infected Patients
Clinical Infectious Diseases2006Vol. 43(9), pp. 1209–1212
Citations Over TimeTop 19% of 2006 papers
M. Núñez, Vincent Soriano, Maria J Lopez, Cristina Ballesteros, Almudena Cascajero, Juan González‐Lahoz, José M. Benito
Abstract
To test the role of hepatitis C virus (HCV) in CD4 cell depletion in human immunodeficiency virus (HIV)-coinfected patients, T cell apoptosis was measured by annexin V labeling in 31 HIV-infected and 30 HIV-HCV-coinfected patients who were not receiving antiretroviral therapy. Apoptosis in naive CD4(+) T cells and in naive and memory CD8(+) T cells was significantly higher in HIV-HCV-coinfected than in monoinfected patients.
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