The Antibody Response to 27‐, 17‐, and 15‐kDaCryptosporidiumAntigens following Experimental Infection in Humans

Citations Over TimeTop 10% of 1998 papers

Abstract

Previous studies have suggested that persons infected with Cryptosporidium parvum develop antibody responses to 27-, 17-, and 15-kDa C. parvum antigens. Studies of volunteers infected with Cryptosporidium species provided an opportunity to evaluate the relationship between antibody reactivity to these antigens and infection outcome. As monitored by immunoblot, increases in specific antibody reactivity were more prevalent among volunteers who developed signs and symptoms of cryptosporidiosis (n = 11) than among asymptomatic infected (n = 7; P = .05) or oocyst-negative volunteers (n = 11; P = .02). Volunteers with preexisting IgG antibody to the 27-kDa antigen excreted fewer oocysts than volunteers without this antibody (P = .003). IgG reactivity to the 17-kDa antigens and IgM reactivity to the 27-kDa antigens were higher at day 0 for asymptomatic infected persons than for those who developed symptoms (P = .03 and P = .04, respectively). These results suggest that characteristic antibody responses develop following C. parvum infection and that persons with preexisting antibodies may be less likely to develop illness.

Related Papers

• → Susceptibility and Serologic Response of Healthy Adults to Reinfection with Cryptosporidium parvum(1998)183 cited
• → Zoonotic transmission of Cryptosporidium parvum: Implications for water-borne cryptosporidiosis(1997)99 cited
• → Cryptosporidium infection in humans and animals from Iraq: A review(2021)16 cited
• Cryptosporidium Contamination in Rural Water Supplies and Cryptosporidium Infestation among Children in Jiangsu Province(2015)
• Detecting methods of cryptosporidium(2008)