Hypercytokinemia and Hyperactivation of Phospho-p38 Mitogen-Activated Protein Kinase in Severe Human Influenza A Virus Infection
Clinical Infectious Diseases2007Vol. 45(6), pp. 723–731
Citations Over TimeTop 10% of 2007 papers
Nelson Lee, Chun Kwok Wong, Paul K.S. Chan, Samantha Wei‐Man Lun, Grace Lui, Billy Tak Ming Wong, David S.C. Hui, Christopher Wai Kei Lam, Clive S. Cockram, Kitty Wai Ying Choi, A C Yeung, Julian W. Tang, Joseph J.�Y. Sung
Abstract
Hypercytokinemia (of proinflammatory and T helper 1 cytokines) is detected in severe influenza, correlating with clinical illness and virus concentration. Hyperactivation of phospho-p38 mitogen-activated protein kinase (in T helper cells) is possibly involved. Early viral suppression may attenuate these potentially deleterious cytokine responses.
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