Classification of Hepatitis B Virus Genotype B into 2 Major Types Based on Characterization of a Novel Subgenotype in Arctic Indigenous Populations
The Journal of Infectious Diseases2007Vol. 196(10), pp. 1487–1492
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Tomoyuki Sakamoto, Yasuhito Tanaka, Josephine Simonetti, Carla Osiowy, Malene Landbo Børresen, Anders Koch, Fuat Kurbanov, Masaya Sugiyama, Gerald Y. Minuk, Brian J. McMahon, Takashi Joh, Masashi Mizokami
Abstract
Hepatitis B virus genotype B (HBV/B) has been classified into 5 subgenotypes. Except for Bj/B1 in Japan, the subgenotypes (Ba/B2-B5) have undergone recombination with HBV/C in the core promoter/precore/core genomic region. Phylogenetic analyses of complete sequences show that the Arctic strains belong to a novel subgenotype (HBV/B6) without the recombination, analogous to what is seen with Bj/B1. Comparison of 50 HBV/B6 carriers from the Arctic versus 50 Bj and 50 Ba age- and sex-matched carriers from Asia revealed that clinical characteristics of HBV/B6 carriers were similar to those of Bj/B1 carriers in Japan. The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2-B5) types.
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